Some guy injected himself with LPS and a TNF-alpha inhibitor to show TNF-alpha mediated the pathology. He's nuts but it worked and led to the development of a new class of life-saving drugs.
Effectiveness of a human monoclonal anti-endotoxin antibody (HA-1A) in gram-negative sepsis: relationship to endotoxin and cytokine levels
CIM is standing on the shoulders of diabulemia https://www.patreon.com/posts/cim-is-standing-101843544